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Interaktion von Pantoprazol mit Cellcept(R) bzw. myfortic(R) (Paperback)
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In vitro Freisetzungsversuche demonstrierten die hohe Stabilität der magensaftresistent formulierten myfortic(R) Tabletten im pH-Bereich von 1-5.
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What Stands Out
Product Details
- Two crossover studies in healthy subjects assessed the bioavailability of Mycophenolic acid and its main metabolite after oral administration of Mycophenolate mofetil (CellCept(R)) or Mycophenolate sodium (myfortic(R)) with concomitant therapy with a proton pump inhibitor (Pantozol(R)) compared to individual intake.
- CellCept(R) showed a 50% reduction in maximum plasma concentrations of Mycophenolic acid under the influence of Pantoprazole, with a 30% decrease in the area under the concentration-time curve during the dosing interval.
- In contrast, the bioavailability of myfortic(R) was not influenced by Pantoprazole.
- In vitro release experiments demonstrated the high stability of myfortic(R) tablets in the pH range of 1-5 and the low water solubility of Mycophenolate mofetil at pH 5.
- This study provides valuable insights into the interaction between Pantoprazole and immunosuppressant drugs like CellCept(R) and myfortic(R), shedding light on their bioavailability and stability under concomitant use.
- Readers will gain a comprehensive understanding of the impact of Pantoprazole on the pharmacokinetics of CellCept(R) and myfortic(R), which is vital for clinical decision-making and patient management.
| Book format | Paperback |
| Fiction/nonfiction | Non-Fiction |
| Genre | Health, Mind & Body |
| Publication date | August, 2012 |
| Pages | 68 |
| Edition | Standard Edition |
| Publisher | KS Omniscriptum Publishing |
| Original languages | German |
| Language | German |
| Assembled product height | 9 in (22.9 cm) |
| Assembled product weight | 0.25 lb (110 grams) |
| Bisac subject heading | Medical |
Who Should Buy?
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Patients on Medications
Individuals taking Cellcept or Myfortic who need to understand Pantoprazol interactions for effective treatment.
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Healthcare Professionals
Doctors and pharmacists looking for detailed insight on drug interactions to provide informed care to patients.
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Research Scholars
Researchers studying drug interactions can benefit from the comprehensive analysis and information found within this paperback.
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General Public
Individuals without medical training may find the content too technical and not directly applicable to everyday issues.
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Low-Dosage Users
Patients on low doses of Pantoprazol may not require detailed interaction analysis, making this book less useful.
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Patients Pregnant
Expectant mothers should consult their healthcare providers for personalized advice rather than relying on this book.
Product Description
Product Buying Guide
This buying guide provides information on the interaction between Pantoprazole and CellCept(R) or myfortic(R) paperback. It includes product specifications, key features, usage scenarios, a comparison with competitors, user reviews, price analysis, buying considerations, and a conclusion.
Product Specifications
- Includes information on the bioavailability of Mycophenolic acid and its main metabolite Mycophenolic acid glucuronide after oral administration of Mycophenolate mofetil (CellCept(R)) or Mycophenolate sodium (myfortic(R)) with concurrent use of a proton pump inhibitor (Pantozol(R))
- Compares the bioavailability of Mycophenolic acid when taken with Pantoprazole versus when taken alone
- Reports a 50% reduction in maximum plasma concentrations of Mycophenolic acid and a 30% decrease in the area under the concentration-time curve during the dosing interval when CellCept(R) is taken with Pantoprazole
- States that the bioavailability of myfortic(R) is not affected by Pantoprazole
- In vitro release tests demonstrate the stability of myfortic(R) tablets in the pH range of 1-5 and the low solubility of Mycophenolate mofetil above pH 5
Key Features
- Provides information on the interaction between Pantoprazole and CellCept(R) or myfortic(R)
- Includes details on the bioavailability of Mycophenolic acid and its metabolites
- Reports the impact of Pantoprazole on the bioavailability of CellCept(R) and myfortic(R)
- Highlights the stability of myfortic(R) tablets in different pH conditions
Usage Scenarios
- For individuals who are prescribed CellCept(R) or myfortic(R) and are also taking Pantoprazole
- To understand how the bioavailability of Mycophenolic acid is affected by the concurrent use of Pantoprazole
- For healthcare professionals, researchers, or individuals interested in the pharmacokinetics of CellCept(R) and myfortic(R)
Buying Considerations
- Consider whether you are taking CellCept(R) or myfortic(R) and if you are also taking Pantoprazole
- Discuss any concerns or questions with your healthcare provider to understand the potential implications of this interaction
- Be aware of the impact on the bioavailability of Mycophenolic acid and adjust dosages as necessary
- Take into account the stability of myfortic(R) tablets in different pH conditions
Conclusion
This buying guide provides important information on the interaction between Pantoprazole and CellCept(R) or myfortic(R). It highlights the impact on the bioavailability of Mycophenolic acid and provides usage scenarios for individuals prescribed these medications. Consideration of this information will help individuals make informed decisions and consult their healthcare providers if necessary.
Customer Questions & Answers
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Question:
What is the pH range in which myfortic(R) tablets are stable?
Answer: myfortic(R) tablets are stable in the pH range of 1-5. -
Question:
What kind of formulation is used for myfortic(R) tablets?
Answer: myfortic(R) tablets are magensaftresistent formulated. -
Question:
Are there any studies demonstrating the stability of myfortic(R) tablets?
Answer: Yes, in vitro release studies have demonstrated the high stability of myfortic(R) tablets.
Korbinian Rupprecht All Books Editorial Review
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Features & Benefits
- High stability of myfortic(R) tablets demonstrated in in vitro release studies.
- Tablets are magensaftresistent formulated.
- Stability maintained in pH range of 1-5.